Postoperative bacterial endophthalmitis: section III
Abel, R.; Binder, P.S.; Bellows, R.
Annals of Ophthalmology 8(10): 1253-1265
1976
ISSN/ISBN: 0003-4886 PMID: 791047 Document Number: 103200
The possible reasons for the poor success rate with antibiotic therapy against postoperative bacterial endophthalmitis includes delay in institution of therapy, poor penetration of selected agents to the area where they are most needed, inadequate dosage, development of bacterial resistance, bacterial products or foreign material that are primarily responsible for the majority of the inflammatory reaction, the inability of vitreous to rapidly clear inflammatory debris and possibly a delay in adjunctive corticosteroid therapy. Therefore, new antimicrobial agents for the prophylaxis and treatment of intraocular infections, ways of improving immunocompetence, better methods of drug delivery, more rapid and exact microbiological diagnosis and newer surgical approaches to aid in the removal of infected tissue should be investigated.