Aspirin and the intraocular pressure rise following aphakic penetrating keratoplasty: a negative report
Zimmerman, T.J.; Binder, P.S.; Abel, R.; Kaufman, H.E.
Annals of Ophthalmology 8(5): 611-614
1976
ISSN/ISBN: 0003-4886 PMID: 779580 Document Number: 103006
Of the 23 patients studied, 12 received aspirin and 11 received placebo. Three patients remained under 40 mm Hg for the postoperative hospital stay and received no glaucoma medication. Two of these patients were in the aspirin group and 1 in the placebo group. The combined keratoplasty and cataract procedures were equally divided between the 2 groups (4 in each group). Vitrectomy was a component of the operative procedure in 8 patients of each group. There was no difference in complications between the 2 groups. The serum salicylate level for the 12 patients receiving aspirin is discussed. There was no bleeding episode associated with the aspirin use although 3 patients complained of tinnitus and their dosage of pills was reduced to 1 instead of 2 every 4 h with resolution of their complaints. One patient was disoriented the 1st morning postoperatively; all medication was stopped and this condition cleared. It is not clear whether this altered consciousness state was due to aspirin toxicity, use of osmotic diuretics or age (82 yr). One patient, on placebo, had hematuria and was given appropriate therapy.