In vitro activity and clinical evaluation of cefixime in urinary tract infection
Asvanich, K.; Fugpholngam, V.; Srimuang, S.; Tanphaichitra, D.
Journal of the Medical Association of Thailand 81(4): 301-304
1998
ISSN/ISBN: 0125-2208 PMID: 9623027 Document Number: 1030
Thirty-five women with uncomplicated acute lower urinary tract infections proven by significant pre-treatment bacteriuria (> or = 10(5)CFU/ml) were treated with an oral dose of 100 mg cefixime twice a day for seven days. Thirty five patients included in this study were checked for response to treatment on the last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and Proteus mirabilis, were inhibited at MIC90 = 0.5 and < or = 0.03 microgram/ml, and MBC = 1 and 0.06 microgram/ml respectively. No adverse events were found in this study.
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