Pharmacologic modification of induced asthma
Falliers, C.J.; Katsampes, C.F.
Annals of Allergy 36(2): 99-103
1976
ISSN/ISBN: 0003-4738 PMID: 175726 Document Number: 102218
Oral adrenergic substances (e.g., ephedrine) and phosphodiesterase inhibitors (e.g., theophylline) can have a prophylactic effect on natural or experimentally induced asthma by maintaining high levels of cyclic AMP in the target organ cells. This controlled, double-blind study evaluates these drugs alone and in a standard dosage combination in blocking asthma induced by the inhalation of pollen allergens among highly selected patients. The results support the claim that oral adrenergic drugs and xanthines can be useful in the prophylaxis of asthma.