Nuclear protein kinase of brain: effect of S-100 protein
Perumal, A.S.
Research Communications in Chemical Pathology and Pharmacology 13(3): 489-496
1976
ISSN/ISBN: 0034-5164 PMID: 180574 Document Number: 102205
The non-histone chromosomal protein fraction isolated from purified brain nuclei possesses protein kinase activity. 93% of this activity is lost by heating at 80 degrees C for 5 min. cAMP does not affect the reaction, but cGMP is inhibitory. In the presence of S-100, an acidic brain-specific protein, phosphate incorporation is enhanced 3 to 4 fold. Bovine serum albumin has no effect whereas histone inhibits activity.
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