Preparation and immunosuppressive potency of equine anti-human thymocyte membrane IgG
Diethelm, A.G.; Chambers, L.M.; Balch, C.M.; Phillips, S.J.
Postgraduate Medical Journal 52(5 Suppl): 55-58
1976
ISSN/ISBN: 0032-5473 PMID: 825846 Document Number: 101939
Anti-human thymocyte cell membrane antibody prepared by hyperimmunization of the horse produced an antiserum capable of prolonging skin allografts in the rhesus monkey for an average of 26 days. Lymphocyte depletion was present in paracortical areas of mesenteric lymph nodes of these animals after 28 days of treatment; the intravenous administration was tolerated without ill effects. Immunofluorescent studies identified both broad specificity antibodies reacting with numerous human cell types as well as thymus-dependent (T) cell antibodies reactive with human thymocytes and peripheral T-cells.