Effects of insulin on cardiac muscle contraction and responsiveness to norepinephrine
Lee, J.C.; Downing, S.E.
American Journal of Physiology 230(5): 1360-1365
1976
ISSN/ISBN: 0002-9513 PMID: 1275078 Document Number: 101874
The effects of insulin (In) on contractile activity of isolated cardiac muscle were studied in right ventricular moderator band (MB) of piglets and papillary muscle (PM) of cats and kittens. The muscles were bathed in modified Krebs solution containing 5.6 mM glucose at 30.degree. C and gassed with 95% O2 and CO2. They were paced at 24 contractions/min isometrically at Lmax were significantly attenuated in the presence of In compared with untreated muscle. In elicits a positive inotropic effect on mammalian cardiac muscle and it impairs the inotropic action of NE.