Association of primary hypothyroidism with preconcious puberty. Presentation of clinical case and the effect of acute inhibition of thyrotropin on the gonadal activity
Cos Welsh, J.
Boletin Medico del Hospital Infantil de Mexico 33(5): 1007-1020
1976
ISSN/ISBN: 0539-6115 PMID: 973854 Document Number: 101860
An 8 2/12 year-old girl with acquired primary hypothyroidism and precociuos puberty is described. Thyroid hormone treatment resulted in the regression of the sexual development, but moderate asymptomatic papilledema appeared as a result of therapy. Serial vaginal smears and measurements of urinary estrogen excretion during acute thyrotropin (TSH) inhibition with 75 mug/day of triiodthyronine (T3), showed a rapid drop in ovaric estrogen production up to prepubertal stage at 17 days of T3 administration. Moreover, a group of children with untreated hypothyroidism was followed through the first 3 to 12 months of thyroid therapy and none developed signs of increased intracranial pressure. These findings as well as the possible pathophysiology involved in this association are discussed.