Characterization of virus-free guinea pig tumors induced by Kirsten sarcoma virus
Rhim, J.S.; Cho, H.Y.; Kim, J.M.; Green, I.
Journal of the National Cancer Institute 56(6): 1233-1236
1976
ISSN/ISBN: 0027-8874 PMID: 62843 Document Number: 101702
Tumors were induced by Kirsten sarcoma virus (KiSV) in an inbred guinea pig, strain 13. The tumor cells were established in culture and characterized. The KiSV-induced sarcoma cells were virus-free and nonproducing; however, they contained resuable sarcoma genome. A type B guinea pig retravirus was readily activated from the tumor cells after induction with 5-bromodeoxyuridine (BUDR). BUDR induction of guinea pig retravirus was further enhanced by treatment with dexamethasone, a synthetic glucocorticoid hormone.